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Psychedelics paired with therapy could treat chronic mental health conditions Research and Innovation Although a rationale for treating autism with LSD might seem obscure on the surface, there is a potential scientific basis for such treatment. Murphy et al. used single-photon emission computed tomography imaging with a 5-HT2A–selective antagonist -radioligand (123I-5-I- R91150) to compare cortical density of 5-HT2A receptors in 10 healthy adult subjects and 8 adults with Asperger’s syndrome. They found that the Asperger’s patients had a significant reduction in cortical 5-HT2A binding in the total, anterior, and posterior cingulate; bilaterally in the frontal and superior temporal lobes; and in the left parietal lobe. They reported that reduced receptor binding was significantly related to abnormal social communication. I was delighted when the editors invited me to write a review on “psychedelics,” perhaps a watershed moment, representing a shift in opinion that has been developi...